Boceprevir | 11-075

Boceprevir | 11-075 | Gentaur UK, US & Europe Distribution

BNR: Chemical

Predicted Molecular Weight: 519, 7

Physical State: Lyophilized

Storage Condition: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Alternate Name: Victrelis; EBP 520; SCH 503034

Background: The antiviral agent boceprevir is a protease inhibitor that covalently and reversibly binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication (Ki = 14nM) by cleaving the virally encoded polyprotein into mature proteins like NS4A, NS4B, NS5A and NS5B. It inhibits the NS3/4A protease in an in vitro HCV replicon system with an EC50 value of 200 nM. Boceprevir has been identified as a potential inhibitor of SARS-CoV-2 responsible for COVID-19. It inhibits SARS-CoV-2 viral replication by targeting the viral main protease Mpro (IC50 = 4.13µM) .

Disclaimer: This product is for research use only.

Purity: greater than or equal to 95% (NMR)

Formula: C27H45N5O5

Source: N/A

Solubility: Soluble in DMSO (15mg/ml), ethanol (20mg/ml) or DMF (20mg/ml) .

InChi Key: LHHCSNFAOIFYRV-DOVBMPENSA-N

Smiles: [H][C@]1 (C2 (C) C) [C@]2 ([H]) CN (C ([C@H] (C (C) (C) C) NC (NC (C) (C) C) =O) =O) [C@]1 ([H]) C (NC (CC3CCC3) C (C (N) =O) =O) =O

RTECS: N/A

Identity: Determined by 1H-NMR.

Merck Index: N/A