Boromycin | B3224

Boromycin is a boron-containing macrolide antibiotic that displays antibacterial, and antiprotozoal properties. Boromycin (3.4 nM) reverses bleomycin-induced cell cycle arrest at the G2 phase in Jurkat cells. It inhibits replication of the HIV-1 strains LAV-1 and RF and the HIV-2 strain LAV-2 in MT-4 cells (IC50s = 0.008, 0.11, and 0.007 µM, respectively. It also inhibits replication of a clinical isolate of HIV-1, strain KK-1, in MT-4 cells and peripheral blood mononuclear cells.

Boromycin is a boron-containing macrolide antibiotic that displays antibacterial, and antiprotozoal properties. Boromycin (3.4 nM) reverses bleomycin-induced cell cycle arrest at the G2 phase in Jurkat cells. It inhibits replication of the HIV-1 strains LAV-1 and RF and the HIV-2 strain LAV-2 in MT-4 cells (IC50s = 0.008, 0.11, and 0.007 µM, respectively. It also inhibits replication of a clinical isolate of HIV-1, strain KK-1, in MT-4 cells and peripheral blood mononuclear cells.

B3224 | Boromycin DataSheet

Alternate Name/Synonyms: NSC-121380,(T-4)-[(1R)-1-[(1S,2R,5S,6R,8R,12R,14S,17R,18S,19R,22S,24Z,28S,30S,33R)-1,2,18,19-tetra(hydroxy-κO)-12,28-dihydroxy-6,13,13,17,29,29,33-heptamethyl-3,20-dioxo-4,7,21,34,35-pentaoxatetracyclo[28.3.1.15,8.114,18]hexatriacont-24-en-22-yl]ethyl D-valinato(4-)]-borate(1-), monohydrogen

Appearance: Off-white solid

Formulation:

CAS Number: 34524-20-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₅H₇₄BNO₁₅

Molecular Weight: 879.9

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A boron-containing macrolide antibiotic

MDL Number:

PubChem CID: 6436027

SMILES: [H][C@@]12O[B-]34O[C@@H](C(=O)O[C@@]([H])(C\C=C/CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@H](C)[C@@]1(O3)O5)[C@@H](C)OC(=O)[C@H]([NH3+])C(C)C)[C@]1(O4)O[C@@]([H])(CC[C@H]1C)C(C)(C)[C@H](O)CCC[C@@H]1C[C@H](OC2=O)[C@@H](C)O1

InChi: InChI=1S/C45H73BNO15/c1-24(2)36(47)39(50)54-27(5)30-16-12-11-13-17-32(48)42(7,8)34-21-19-26(4)45(57-34)38-41(52)56-31-23-29(53-28(31)6)15-14-18-33(49)43(9,10)35-22-20-25(3)44(58-35)37(40(51)55-30)59-46(60-38,61-44)62-45/h11-12,24-38,48-49H,13-23,47H2,1-10H3/q-1/p+1/b12-11+/t25-,26-,27-,28-,29-,30+,31+,32+,33-,34+,35+,36-,37?,38?,44+,45+,46?/m1/s1

InChi Key: OOBFYEMEQCZLJL-XURNZCJASA-O