Borrelidin | 2367

A macrolide antibiotic isolated from Streptomyces sp. An antiangiogenic (IC₅₀ = 0.8 nM) agent. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Also acts as a CDK inhibitor.

Borrelidin is an antiangiogenic (IC₅₀ = 0.8 nM) agent. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Induces the collapse of formed capillary tubes in a dose-dependent fashion.

2367 | Borrelidin DataSheet

Alternate Name/Synonyms: Treponemycin; U 78548; C2989

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 7184-60-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₄₃NO₆

Molecular Weight: 489.64

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: An angiogenesis inhibitor

MDL Number: MFCD01740784

PubChem CID: 6436801

SMILES: CC1CC(CC(C(C(=CC=CCC(OC(=O)CC(C(C1)C)O)C2CCCC2C(=O)O)C#N)O)C)C

InChi: InChI=1S/C28H43NO6/c1-17-12-18(2)14-20(4)27(32)21(16-29)8-5-6-11-25(22-9-7-10-23(22)28(33)34)35-26(31)15-24(30)19(3)13-17/h5-6,8,17-20,22-25,27,30,32H,7,9-15H2,1-4H3,(H,33,34)/b6-5+,21-8-/t17-,18+,19-,20-,22+,23+,24-,25-,27+/m0/s1

InChi Key: OJCKRNPLOZHAOU-UGKRXNSESA-N