BPGM Antibody | 23-250

BPGM Antibody | 23-250 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-259 of human BPGM (NP_001715.1) .

Research Area: Cancer, Signal Transduction

Tested Application: WB, IHC

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Specificiy: N/A

Positive Control 1: 293T

Positive Control 2: Jurkat

Positive Control 3: HeLa

Positive Control 4: Mouse liver

Positive Control 5: Mouse spleen

Positive Control 6: Mouse testis

Molecular Weight: Observed: 30kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: Bisphosphoglycerate mutase, BPGM, 3-bisphosphoglycerate mutase, erythrocyte, 3-bisphosphoglycerate synthase, 3-diphosphoglycerate mutase, DPGM, BPG-dependent PGAM, BPGM

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: 2, 3-diphosphoglycerate (2, 3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2, 3-DPG synthesis via its synthetase activity, and 2, 3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified.