BQ-610 | B1553

BQ-610 is a highly potent and selective ETAR (ETA receptor) antagonist (IC₅₀ = 20 nM) that ttenuates ET-induced reduction in cardiac output. It also inhibits ET-1- and ET-3-induced activation of adenylate cyclase (IC₅₀ = 28.2 nM). BQ-610 is 30-fold more potent ETA antagonist than BQ-123 in pig aortic smooth muscle membrane assay, same activity as BQ-123 when tested on pig cerebellum membrane.

BQ-610 is a highly potent and selective ETAR (ETA receptor) antagonist (IC₅₀ = 20 nM) that ttenuates ET-induced reduction in cardiac output. It also inhibits ET-1- and ET-3-induced activation of adenylate cyclase (IC₅₀ = 28.2 nM). BQ-610 is 30-fold more potent ETA antagonist than BQ-123 in pig aortic smooth muscle membrane assay, same activity as BQ-123 when tested on pig cerebellum membrane.

B1553 | BQ-610 DataSheet

Alternate Name/Synonyms: AZEPANE-1-CARBONYL-LEU-D-TRP(FOR)-D-TRP-OH; Hexahydroazepinocarbonyl-leu-D-trp(cho)-D-trp

Appearance: White lyophilized solid

Formulation: N/A

CAS Number: 141595-53-1

Structure Available?: Yes

Peptide sequence: Unk-Leu-D-Trp(For)-D-Trp-OH

Salt Form: N/A

Molecular Formula: C₃₆H₄₄N₆O₆

Molecular Weight: 656.79

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: H₂O ( 1 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A highly potent and selective ETAR (ETA receptor) antagonist

MDL Number: MFCD00270700

PubChem CID: 123905

SMILES: CC(C)CC(C(=O)NC(CC1=CN(C2=CC=CC=C21)C=O)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)O)NC(=O)N5CCCCCC5

InChi: InChI=1S/C36H44N6O6/c1-23(2)17-29(40-36(48)41-15-9-3-4-10-16-41)33(44)38-30(19-25-21-42(22-43)32-14-8-6-12-27(25)32)34(45)39-31(35(46)47)18-24-20-37-28-13-7-5-11-26(24)28/h5-8,11-14,20-23,29-31,37H,3-4,9-10,15-19H2,1-2H3,(H,38,44)(H,39,45)(H,40,48)(H,46,47)/t29-,30+,31+/m0/s1

InChi Key: QHSRPPJQBFQWSC-OJDZSJEKSA-N