BQCA | B2265

BQCA is a potent M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with selectivity for M1 over M2-M5. The effective range for potentiation of M1 in cells by BQCA is 0.1 to 100 μM with an inflection point value of 845 nM when 3 nM acetylcholine is used. BQCA displays no potentiation, agonism, or antagonism at other mAChRs at concentrations up to 100 μM.

BQCA is a potent M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with selectivity for M1 over M2-M5. The effective range for potentiation of M1 in cells by BQCA is 0.1 to 100 μM with an inflection point value of 845 nM when 3 nM acetylcholine is used. BQCA displays no potentiation, agonism, or antagonism at other mAChRs at concentrations up to 100 μM.

B2265 | BQCA DataSheet

Alternate Name/Synonyms: 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Benzyl quinolone carboxylic acid

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 338747-41-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₅NO₄

Molecular Weight: 309.32

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator

MDL Number: MFCD01315710

PubChem CID: 1476756

SMILES: COC1=CC=C(C=C1)CN2C=C(C(=O)C3=CC=CC=C32)C(=O)O

InChi: InChI=1S/C18H15NO4/c1-23-13-8-6-12(7-9-13)10-19-11-15(18(21)22)17(20)14-4-2-3-5-16(14)19/h2-9,11H,10H2,1H3,(H,21,22)

InChi Key: BZBBTGCKPRSPGF-UHFFFAOYSA-N