Branebrutinib | B2998

Branebrutinib is a potent covalent, irreversible inhibitor of Bruton's tyrosine kinase (BTK). BTK is a non-receptor tyrosine kinase. It is a member of the Tec family of kinases and is essential for B cell receptor (BCR) mediated signaling. Branebrutinib inhibits BTK with IC₅₀ values of 0.1 nM, 0.9 nM, 1.5 nM and 5 nM for BTK, TEC, BMX and TXK respectively. It inactivates BTK in the human whole blood assay rapidly at a rate of 3.5 × 10−4 nM−1min-1. Branebrutinib inhibits signaling and functional end points, including calcium flux (IC₅₀ = 7 nM), production of cytokines, proliferation, and surface expression of the costimulatory molecule CD86 (IC₅₀ values < 1 nM) in B cells stimulated through the B cell receptor.

Branebrutinib is a potent covalent, irreversible inhibitor of Bruton's tyrosine kinase (BTK). BTK is a non-receptor tyrosine kinase. It is a member of the Tec family of kinases and is essential for B cell receptor (BCR) mediated signaling. Branebrutinib inhibits BTK with IC₅₀ values of 0.1 nM, 0.9 nM, 1.5 nM and 5 nM for BTK, TEC, BMX and TXK respectively. It inactivates BTK in the human whole blood assay rapidly at a rate of 3.5 × 10−4 nM−1min-1. Branebrutinib inhibits signaling and functional end points, including calcium flux (IC₅₀ = 7 nM), production of cytokines, proliferation, and surface expression of the costimulatory molecule CD86 (IC₅₀ values < 1 nM) in B cells stimulated through the B cell receptor.

B2998 | Branebrutinib DataSheet

Alternate Name/Synonyms: BMS-986195; 4-[(3S)-3-(but-2-ynoylamino)piperidin-1-yl]-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide

Appearance: White to off-White Solid Powder

Formulation:

CAS Number: 1912445-55-6

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₀H₂₃FN₄O₂

Molecular Weight: 370.42

Cell-Permeable?: TRUE

Purity: >98%

Solubilities: ~35 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent inhibitor of BTK

MDL Number: MFCD31631584

PubChem CID: 121293929

SMILES: CC#CC(=O)NC1CCCN(C1)C2=C(C=C(C3=C2C(=C(N3)C)C)C(=O)N)F

InChi: InChI=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18-17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/t13-/m0/s1

InChi Key: VJPPLCNBDLZIFG-ZDUSSCGKSA-N