BRAP Antibody (N-term) [APR15169G]

BRAP Antibody (N-term) [APR15169G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This BRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-95 amino acids from the N-terminal region of human BRAP.

Cellular Localisation: Cytoplasm.

Molecular Weight: 67305

Clone: Polyclonal

Gene Name: BRAP (HGNC:1099)

Gene ID: 8315

Function: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Summary: Tissue Location: Expressed in breast epithelial cell lines.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: BRCA1-associated protein, 632-, BRAP2, Impedes mitogenic signal propagation, IMP, RING finger protein 52, Renal carcinoma antigen NY-REN-63, BRAP (HGNC:1099), RNF52