BRCA2 (N60) polyclonal Antibody | BS2864

BRCA2 (N60) polyclonal Antibody | BS2864 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: BRCA 2 is localized to chromosome 13q12 - q13. Loss of heterozygosity of 13q is observed in 25% of sporadic breast tumors, which indicates that BRCA 2 might be a tumor suppressor gene. BRCA 2 confers only a low ovarian cancer risk. Reportedly, in MCF-10F (normal breast epithelial cell line) and MCF-7 (breast cancer cell line) cells the expression of BRCA 2 RNA lowers in G0 and early G1 phases then gets up-regulated at the G1 / S phase junction.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: BRCA2 (N60) polyclonal Antibody detects endogenous levels of BRCA2 protein.

Molecular Weight: ~ 384 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Fanconi anemia group D1 protein; Breast cancer type 2 susceptibility protein; BRCA2; FACD; FANCD1

Immunogen: Synthetic peptide, corresponding to amino acids 60-100 of Human BRCA2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: