BRD-7552 | B2258

BRD-7552 is an inducer of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD-7552 dose-dependently increases PDX1 and insulin gene expression, as well as PDX1 protein levels, in PANC-1 cells. It also increases acetylation of histone H3 and trimethylation of H3K4 and H3K9.

BRD-7552 is an inducer of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD-7552 dose-dependently increases PDX1 and insulin gene expression, as well as PDX1 protein levels, in PANC-1 cells. It also increases acetylation of histone H3 and trimethylation of H3K4 and H3K9.

B2258 | BRD-7552 DataSheet

Alternate Name/Synonyms: Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4

Appearance: Off-white solid

Formulation: N/A

CAS Number: 1137359-47-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₃H₃₃N₃O₁₅

Molecular Weight: 711.63

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>60 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A pancreatic and duodenal homeobox 1 (PDX1) inducer

MDL Number: MFCD28133407

PubChem CID: 23891512

SMILES: CCOC(=O)C1=CC=C(C=C1)NC(=O)OC2C(OC(C(C2OC(=O)NC3=CC4=C(C=C3)OCO4)OC(=O)NC5=CC6=C(C=C5)OCO6)OC)CO

InChi: InChI=1S/C33H33N3O15/c1-3-43-29(38)17-4-6-18(7-5-17)34-31(39)49-26-25(14-37)48-30(42-2)28(51-33(41)36-20-9-11-22-24(13-20)47-16-45-22)27(26)50-32(40)35-19-8-10-21-23(12-19)46-15-44-21/h4-13,25-28,30,37H,3,14-16H2,1-2H3,(H,34,39)(H,35,40)(H,36,41)/t25-,26-,27+,28-,30+/m1/s1

InChi Key: AAOLIMLEFKWKOY-IXMSMLDRSA-N