BRD4770 | 9525

BRD4770 is a selective inhibitor of the histone methyltransferase G9a (also named euchromatin histone methyltransferase 2 (EHMT2). BRD4770 blocks lysine residue 9 methylation of histone H3 without inducing apoptosis. In addition, it induces senescence, and inhibits both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1.

BRD4770 is a selective inhibitor of the histone methyltransferase G9a (also named euchromatin histone methyltransferase 2 (EHMT2). BRD4770 blocks lysine residue 9 methylation of histone H3 without inducing apoptosis. In addition, it induces senescence, and inhibits both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1.

9525 | BRD4770 DataSheet

Alternate Name/Synonyms: Methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1374601-40-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₃N₃O₃

Molecular Weight: 413.47

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO(10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An inhibitor of histone methyltransferase G9a

MDL Number: N/A

PubChem CID: 72193870

SMILES: COC(=O)C1=CC2=C(C=C1)N(C(=N2)NC(=O)C3=CC=CC=C3)CCCC4=CC=CC=C4

InChi: InChI=1S/C25H23N3O3/c1-31-24(30)20-14-15-22-21(17-20)26-25(27-23(29)19-12-6-3-7-13-19)28(22)16-8-11-18-9-4-2-5-10-18/h2-7,9-10,12-15,17H,8,11,16H2,1H3,(H,26,27,29)

InChi Key: UCGWYCMPZXDHNR-UHFFFAOYSA-N