BRD6929 | B2931

BRD6929 is a benzamide-based brain-penetrant inhibitor of Histone deacetylases HDAC1 and HDAC2. It increases histone acetylation and inhibits HDAC1 and HDAC2 with an IC₅₀ of 1 nM and 8 nM respectively. It shows 50–400 fold selectivity over HDAC3 with an IC₅₀ of 458 nM. Chronic treatment with BRD6929 improves mood-related behaviors in mice.

BRD6929 is a benzamide-based brain-penetrant inhibitor of Histone deacetylases HDAC1 and HDAC2. It increases histone acetylation and inhibits HDAC1 and HDAC2 with an IC₅₀ of 1 nM and 8 nM respectively. It shows 50–400 fold selectivity over HDAC3 with an IC₅₀ of 458 nM. Chronic treatment with BRD6929 improves mood-related behaviors in mice.

B2931 | BRD6929 DataSheet

Alternate Name/Synonyms: 4-(Acetylamino)-N-[2-amino-5-(2-thienyl)phenyl]-benzamide; Compound 60; TPB; HDAC1 & 2 Inhibitor

Appearance: Solid

Formulation:

CAS Number: 849234-64-6

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₉H₁₇N₃O₂S

Molecular Weight: 351.42

Cell-Permeable?: True

Purity: 97%

Solubilities: 2 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective inhibitor of HDAC1 and 2

MDL Number: MFCD16495786

PubChem CID: 349358485

SMILES: O=C(NC1=CC(C2=CC=CS2)=CC=C1N)C3=CC=C(NC(C)=O)C=C3

InChi: InChI=1S/C19H17N3O2S/c1-12(23)21-15-7-4-13(5-8-15)19(24)22-17-11-14(6-9-16(17)20)18-3-2-10-25-18/h2-11H,20H2,1H3,(H,21,23)(H,22,24)

InChi Key: ABZSPJVXTTUFAA-UHFFFAOYSA-N