Brequinar Sodium | B2637

Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Blocks de novo pyrimidine biosynthesis. Displays minimal inhibition against a panel of >400 kinases. Triggers differentiation of AML cell lines. Causes differentiation and depletion of leukemia-initiating cells in vivo. Antimetabolite.

Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Blocks de novo pyrimidine biosynthesis. Displays minimal inhibition against a panel of >400 kinases. Triggers differentiation of AML cell lines. Causes differentiation and depletion of leukemia-initiating cells in vivo. Antimetabolite.

B2637 | Brequinar Sodium DataSheet

Alternate Name/Synonyms: NSC 368390; 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium; Dup 785; BRQ

Appearance: White solid

Formulation:

CAS Number: 96201-88-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₁₄F₂NO₂Na

Molecular Weight: 397.35

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >35 mg/ml in DMSO, >35 mg/ml in Water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor

MDL Number:

PubChem CID: 23663964

SMILES: CC1=C(C2=CC(F)=CC=C2N=C1C3=CC=C(C4=C(C=CC=C4)F)C=C3)C(O[Na])=O

InChi: InChI=1S/C23H15F2NO2.Na/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25;/h2-12H,1H3,(H,27,28);/q;+1/p-1

InChi Key: PZOHOALJQOFNTB-UHFFFAOYSA-M