Brigatinib analog | B2025

Brigantinib alalog is an analog of Brigatinib (AP26113) (Cat.No. 9675), a phosphine oxide-containing ALK inhibitor. It potently inhibits ALK (IC₅₀ = 0.07 nM) over IGF-1R and InsR (IC₅₀s = 3.2 and 100 nM, respectively.

Brigantinib alalog is an analog of Brigatinib (AP26113) (Cat.No. 9675), a phosphine oxide-containing ALK inhibitor. It potently inhibits ALK (IC₅₀ = 0.07 nM) over IGF-1R and InsR (IC₅₀s = 3.2 and 100 nM, respectively.

B2025 | Brigatinib analog DataSheet

Alternate Name/Synonyms: (2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide; AP-26113 analog; ALK-IN-1

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1197958-12-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₃₄ClN₆O₂P

Molecular Weight: 529.01

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent ALK inhibitor

MDL Number: N/A

PubChem CID: 57390074

SMILES: CN(C)C1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4P(=O)(C)C)Cl)OC

InChi: InChI=1S/C26H34ClN6O2P/c1-32(2)18-12-14-33(15-13-18)19-10-11-21(23(16-19)35-3)30-26-28-17-20(27)25(31-26)29-22-8-6-7-9-24(22)36(4,5)34/h6-11,16-18H,12-15H2,1-5H3,(H2,28,29,30,31)

InChi Key: OVDSPTSBIQCAIN-UHFFFAOYSA-N