BRM polyclonal Antibody | BS5631

BRM polyclonal Antibody | BS5631 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: The Brahma protein (Brm) is an ATPase subunit of the Drosophila melanogaster Brm complex, which is highly related to the mammalian SWI/SNF chromatin-remodeling complex. Brm is a transcriptional activator of Hox genes and associates with nearly all transcriptionally active chromatin in a pattern that is non-overlapping with that of Polycomb, a repressor of Hox gene transcription. The Brm complex is an essential coactivator for the trithorax group protein Zeste, a DNA-binding activator of homeotic genes. Reduction of Brm function dramatically reduces the association of RNA polymerase II with Drosophila salivary gland chromosomes, suggesting that the chromatin remodeling activity of the Brm complex plays a general role in facilitating transcription by RNA polymerase II. Brm acts as a dominant suppressor of the rough eye phenotype that results from a hypomorphic mutation of Drosophila cyclin E by inhibiting S phase entry by acting downstream of cyclin E protein accumulation. The interaction of the Brm complex with chromatin may be modulated by BAP111, which is highly associated with the Brm complex in Drosophila embryos via an HMG domain. Brm is highly expressed in unfertilized eggs and early embryos.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: BRM polyclonal Antibody detects endogenous levels of BRM protein.

Molecular Weight: ~ 210 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Probable global transcription activator SNF2L2; ATP-dependent helicase SMARCA2; BRG1-associated factor 190B; BAF190B; Protein brahma homolog; hBRM; SNF2-alpha; SNF2-α; SNF2α; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; SMARCA2; BAF190B; SNF2A; SNF2L2

Immunogen: Synthetic peptide, corresponding to amino acids 1387-1432 of Human BRM.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: