BSCL2 Antibody (N-term) [APR30549G]

BSCL2 Antibody (N-term) [APR30549G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This BSCL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-107 amino acids from the N-terminal region of human BSCL2.

Cellular Localisation: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet Note=Localizes at endoplasmic reticulum-lipid droplets (ER-LD) contact sites.

Molecular Weight: 44392

Clone: Polyclonal

Gene Name: BSCL2

Gene ID: 26580

Function: Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:19278620, PubMed:21533227, PubMed:31708432, PubMed:30293840) . In association with LDAF1, defines the sites of LD formation in the ER (PubMed:31708432) . Also required for growth and maturation of small nascent LDs into larger mature LDs (PubMed:27564575) . Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs (PubMed:31178403, PubMed:27879284) . Regulates the maturation of ZFYVE1- positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts (PubMed:30970241) . Binds anionic phospholipids including phosphatidic acid (PubMed:30293840) . Plays an important role in the differentiation and development of adipocytes (By similarity) .

Summary: Tissue Location: Expressed in motor neurons in the spinal cord and cortical neurons in the frontal lobe (at protein level) . Highly expressed in brain, testis and adipose tissue

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: WB--1:2000 WB--1:1000 IHC-P--1:100~500

Synonyms: Seipin, Bernardinelli-Seip congenital lipodystrophy type 2 protein, BSCL2