BT2 (BCKDC Kinase Inhibitor) | B2764

BT2 is an inhibitor of the mitochondrial branched-chain a-ketoacid dehydrogenase complex kinase (BCKDC) - IC50 = 3.19 µM. Inhibition of this kinase has been shown to reduce levels of branched-chain amino acid concentrations in vivo. BT2 also acts as a moderate inhibitor (Ki = 59 µM) of myeloid cell leukemia 1(Mcl 1), a Bcl-2 family protein.

BT2 is an inhibitor of the mitochondrial branched-chain a-ketoacid dehydrogenase complex kinase (BCKDC) - IC50 = 3.19 µM. Inhibition of this kinase has been shown to reduce levels of branched-chain amino acid concentrations in vivo. BT2 also acts as a moderate inhibitor (Ki = 59 µM) of myeloid cell leukemia 1(Mcl 1), a Bcl-2 family protein.

B2764 | BT2 (BCKDC Kinase Inhibitor) DataSheet

Alternate Name/Synonyms: 3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid

Appearance: Off-white solid

Formulation:

CAS Number: 34576-94-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₉H₄Cl₂O₂S

Molecular Weight: 247.1

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: ~20 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A BCKDC kinase inhibitor

MDL Number:

PubChem CID: 739884

SMILES: C1=CC2=C(C=C1Cl)SC(=C2Cl)C(=O)O

InChi: InChI=1S/C9H4Cl2O2S/c10-4-1-2-5-6(3-4)14-8(7(5)11)9(12)13/h1-3H,(H,12,13)

InChi Key: AAHPIJMQJAZYTM-UHFFFAOYSA-N