BTK Inhibitor, PCI-32765 | 2298

A potent and highly selective small-molecule inhibitor of Bruton's tyrosine kinase (BTK) (IC₅₀ = 0.5 nM) with potential antineoplastic activity. It.binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK.

PCI-32765 is a potent and highly selective small-molecule inhibitor of Bruton's tyrosine kinase (BTK) (IC₅₀ = 0.5 nM) with potential antineoplastic activity.

2298 | BTK Inhibitor, PCI-32765 DataSheet

Alternate Name/Synonyms: 2-propen-1-one, 1-((3R)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo(3,4-d)pyrimidin-1-yl)-1-piperidinyl)-; Ibrutinib; CRA-032765

Appearance: White solid

Formulation: N/A

CAS Number: 936563-96-1

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₂₅H₂₄N₆O₂

Molecular Weight: 440.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>80 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent Bruton's Tyrosine Kinase (BTK) inhibitor

MDL Number: MFCD20261150

PubChem CID: 16126651

SMILES: C=CC(=O)N1CCCC(C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N

InChi: InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)

InChi Key: XYFPWWZEPKGCCK-UHFFFAOYSA-N