Bufalin | 2509

Bufalin is cardioactive steroid that exhibits a variety of biological activities, such as cardiotonic, anaesthetic, blood pressure stimulatory, respiratory and antineoplastic effects. Acts as a specific Na⁺/K⁺-ATPase inhibitor. More potent than ouabain. Induces cell differentiation. Induces apoptosis in U937 and HL-60 cells by activation of AP-1 via a MAPK pathway that involves JNK. Regulates Tiam1 gene. Down regulates expression of 14-3-3 protein.

Bufalin is cardioactive steroid that exhibits a variety of biological activities, such as cardiotonic, anaesthetic, blood pressure stimulatory, respiratory and antineoplastic effects. Acts as a specific Na⁺/K⁺-ATPase inhibitor. More potent than ouabain.

2509 | Bufalin DataSheet

Alternate Name/Synonyms: 3β,14-Dihydroxy-5β,20(22)-bufadienolide, 5β,20(22)-Bufadienolide-3β,14-diol

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 465-21-4

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₂₄H₃₄O₄

Molecular Weight: 386.52

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~25 mg/ml) or EtOH (~ 25 mg/ml, warm)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A specific Na⁺/K⁺-ATPase inhibitor

MDL Number: MFCD00056525

PubChem CID: 9547215

SMILES: CC12CCC(CC1CCC3C2CCC4(C3(CCC4C5=COC(=O)C=C5)O)C)O

InChi: InChI=1S/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19+,20-,22+,23-,24+/m1/s1

InChi Key: QEEBRPGZBVVINN-BMPKRDENSA-N