BVT948 | B1810

BVT 948 is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTP; IC₅₀s = 0.09-1.7 µM). displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo.

BVT 948 is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTP; IC₅₀s = 0.09-1.7 µM). displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo.

B1810 | BVT948 DataSheet

Alternate Name/Synonyms: 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione

Appearance: Red solid

Formulation: N/A

CAS Number: 39674-97-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₄H₁₁NO₃

Molecular Weight: 241.25

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases

MDL Number: MFCD00616487

PubChem CID: 6604934

SMILES: CC1(C2=C(C3=CC=CC=C3C(=O)C2=O)NC1=O)C

InChi: InChI=1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6H,1-2H3,(H,15,18)

InChi Key: LLPBUXODFQZPFH-UHFFFAOYSA-N