BX-320 | B2916

BX-320 is an inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1). The phosphoinositide 3-kinase/PDK1/Akt signaling pathway plays an important role in cancer cell growth, survival and angiogenesis. BX-320 inhibits PDK1 enzyme activity in a kinase assay with an IC₅₀ of 30 nM. BX-320 blocks the growth of MDA-453, U87-MG and PC-3 cells in soft agar with IC₅₀ values of 0.093 μM, 0.3 μM and 0.4 μM respectively. BX-320 inhibits the growth of LOX melanoma tumors in mice models.

BX-320 is an inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1). The phosphoinositide 3-kinase/PDK1/Akt signaling pathway plays an important role in cancer cell growth, survival and angiogenesis. BX-320 inhibits PDK1 enzyme activity in a kinase assay with an IC₅₀ of 30 nM. BX-320 blocks the growth of MDA-453, U87-MG and PC-3 cells in soft agar with IC₅₀ values of 0.093 μM, 0.3 μM and 0.4 μM respectively. BX-320 inhibits the growth of LOX melanoma tumors in mice models.

B2916 | BX-320 DataSheet

Alternate Name/Synonyms: N1-[3-[[5-Bromo-2-[[3-[(1-pyrrolidinylcarbonyl)amino]phenyl]amino]-4-pyrimidinyl]amino]propyl]-2,2-dimethylpropanediamide; UNII-B504GXS5SM; N-(3-{[5-Bromo-2-({3-[(Pyrrolidin-1-ylcarbonyl)amino]phenyl}amino)Pyrimidin-4-yl]amino}propyl)-2,2-dimethylmalonamide; N-(3-(4-(3-(3-amino-2,2-dimethyl-3-oxopropanamido)propylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide

Appearance: Solid

Formulation:

CAS Number: 702676-93-5

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₃H₃₁BrN₈O₃

Molecular Weight: 547.45

Cell-Permeable?: True

Purity: 95%

Solubilities: Soluble in DMSO in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of PDK1

MDL Number:

PubChem CID: 657138

SMILES: CC(C)(C(=O)N)C(=O)NCCCNC1=NC(=NC=C1Br)NC2=CC(=CC=C2)NC(=O)N3CCCC3

InChi: InChI=1S/C23H31BrN8O3/c1-23(2,19(25)33)20(34)27-10-6-9-26-18-17(24)14-28-21(31-18)29-15-7-5-8-16(13-15)30-22(35)32-11-3-4-12-32/h5,7-8,13-14H,3-4,6,9-12H2,1-2H3,(H2,25,33)(H,27,34)(H,30,35)(H2,26,28,29,31)

InChi Key: