C-DIM 12 | B2146

C-DIM 12 activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Nurr1 is a suppressor of NF-kB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses inflammatory signaling in these cells. Displays neuroprotective activity in a mouse model of progressive neurodegeneration with a strong neuroinflammatory component (50 mg/Kg, oral).

C-DIM 12 activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Nurr1 is a suppressor of NF-kB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses inflammatory signaling in these cells. Displays neuroprotective activity in a mouse model of progressive neurodegeneration with a strong neuroinflammatory component (50 mg/Kg, oral).

B2146 | C-DIM 12 DataSheet

Alternate Name/Synonyms: 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]

Appearance: Orange powder

Formulation: N/A

CAS Number: 178946-89-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₁₇ClN₂

Molecular Weight: 356.9

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (35 mg/ml) or EtOH (35 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Orphan nuclear receptor Nurr1 activator

MDL Number: N/A

PubChem CID: 5302583

SMILES: C1=CC=C2C(=C1)C(=CN2)C(C3=CC=C(C=C3)Cl)C4=CNC5=CC=CC=C54

InChi: InChI=1S/C23H17ClN2/c24-16-11-9-15(10-12-16)23(19-13-25-21-7-3-1-5-17(19)21)20-14-26-22-8-4-2-6-18(20)22/h1-14,23,25-26H

InChi Key: LTLRXTDMXOFBDW-UHFFFAOYSA-N