c-Jun (Phospho-S63) polyclonal Antibody | BS94032

c-Jun (Phospho-S63) polyclonal Antibody | BS94032 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC IHC

Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:100

Background: Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA) -induced expression of responsive genes through the TPA-response element (TRE) . The Jun proteins form homo- and heterodimers which bind the TRE, while Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. An inhibitor of Fos/Jun function, termed IP-1, associates with Fos and Jun and is inactivated upon phosphorylation induced by the cAMP-dependent protein kinase A (PKA) .

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: c-Jun (Phospho-S63) polyclonal Antibody detects endogenous levels of c-Jun protein only when phosphorylated at S63.

Molecular Weight: 40 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: AP1, JUN, Activator protein 1, AP 1, AP1, cJun, Enhancer Binding Protein AP1, Jun Activation Domain Binding Protein, JUN, Jun oncogene, JUN protein, Jun proto oncogene, JUN, JUNC, Oncogene JUN, p39, Proto oncogene c jun, Proto oncogene cJun, Proto-oncogene c-jun, Transcription Factor AP 1, Transcription factor AP-1, Transcription Factor AP1, V jun avian sarcoma virus 17 oncogene homolog, V jun sarcoma virus 17 oncogene homolog (avian), V jun sarcoma virus 17 oncogene homolog, V-jun avian sarcoma virus 17 oncogene homolog, vJun Avian Sarcoma Virus 17 Oncogene Homolog,

Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser63 of human c-Jun.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: ProA affinity purified

Pathway: