C109B Antibody (C-term) [APR03680G]

C109B Antibody (C-term) [APR03680G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This C109B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-320 amino acids from the C-terminal region of human C109B.

Cellular Localisation: Mitochondrion inner membrane; Multi-pass membrane protein

Molecular Weight: 39082

Clone: Polyclonal

Gene Name: MCUB {ECO:0000303|PubMed:24231807, ECO:0000312|HGNC:HGNC:26076}

Gene ID: 55013

Function: Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Calcium uniporter regulatory subunit MCUb, mitochondrial, MCUb, Coiled-coil domain-containing protein 109B, CCDC109B, MCUB