C12orf48 Antibody (C-term) [APR30544G]

C12orf48 Antibody (C-term) [APR30544G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This C12orf48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 522-550 amino acids from the C-terminal region of human C12orf48.

Cellular Localisation: Cytoplasm. Nucleus Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA

Molecular Weight: 65054

Clone: Polyclonal

Gene Name: PARPBP

Gene ID: 55010

Function: Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly (A) homopolymers. Positively regulate the poly (ADP-ribosyl) ation activity of PARP1; however such function may be indirect.

Summary: Tissue Location: Restricted to testis. Overexpressed in multiple cancer cells.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: PCNA-interacting partner, PARI, PARP-1 binding protein, PARP1-binding protein, PARPBP, PARPBP, C12orf48, PARI