C13orf18 Antibody (Center) [APR05689G]

C13orf18 Antibody (Center) [APR05689G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This C13orf18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 379-405 amino acids from the Central region of human C13orf18.

Cellular Localisation: Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Note=Associates with late autophagic structure (PubMed:28306502) . Recruitment to autophagosome membrane is promoted by autophagic stimuli (PubMed:28306502)

Molecular Weight: 73457

Clone: Polyclonal

Gene Name: RUBCNL (HGNC:20420)

Gene ID: 80183

Function: Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns (3) P) in late steps of autophagy (PubMed:28306502, PubMed:30704899) . Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502) . Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502) . Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns (3) P), 4- phosphate (PtdIns (4) P) and 5-phosphate (PtdIns (5) P) (PubMed:28306502) . In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity) . May act as a tumor suppressor (Probable) .

Summary: Tissue Location: Expressed weakly in cervical carcinoma cell lines.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: FC, WB

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Uncharacterized protein KIAA0226-like, KIAA0226L, C13orf18