C14orf126 Antibody (C-term) [APG02306G]

C14orf126 Antibody (C-term) [APG02306G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This C14orf126 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from the C-terminal region of human C14orf126.

Cellular Localisation: Cytoplasm.

Molecular Weight: 18660

Clone: Polyclonal

Gene Name: DTD2

Gene ID: 112487

Function: Deacylates mischarged D-aminoacyl-tRNAs (By similarity) . Also deacylates mischarged glycyl-tRNA (Ala), protecting cells against glycine mischarging by AlaRS (By similarity) . Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity) . Catalyzes the hydrolysis of D-tyrosyl-tRNA (Tyr), has no activity on correctly charged L-tyrosyl- tRNA (Tyr) (By similarity) . By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA (Thr) (G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408) . Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408) . Also hydrolyzes correctly charged, achiral, glycyl-tRNA (Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA (Gly) from DTD2- mediated deacetylation (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Probable D-tyrosyl-tRNA (Tyr) deacylase 2, 31--, D-tyrosyl-tRNA deacylase 2, DTD2, C14orf126