C1orf19 Polyclonal Antibody | BS65476

C1orf19 Polyclonal Antibody | BS65476 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep,

Application: IHC-P,

Application Range: IHC-P=1:100-500

Background: SEN15, also known as TSEN15 (tRNA-splicing endonuclease subunit Sen15) or C1orf19, is a nuclear protein that plays a role in tRNA splicing. Widely expressed with highest expression in testis and uterus, SEN15 is a non-catalytic subunit of the multi-protein tRNA-splicing endonuclease complex. The endonuclease complex is responsible for identifying and cleaving pre-tRNA at both 5’ and 3’ splice sites, thereby releasing introns and free tRNA molecules with 2',3' cyclic phosphates and 5'-OH termini. In addition to its role in pre-tRNA splicing, the endonuclease complex participates in mRNA processing and, via its association with pre-mRNA processing factors, is thought to link pre-tRNA and pre-mRNA splicing events. As a subunit of the complex, SEN15 participates in protein expression and, ultimately, cell growth and division.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: C1orf19 Polyclonal Antibody detects endogenous levels of C1orf19 protein.

Molecular Weight: 17 kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Chromosome 1 open reading frame 19; Chromosome 1 open reading frame 19, isoform CRA_c; HsSen15; sen15; SEN15 homolog; SEN15_HUMAN; tRNA intron endonuclease Sen15; tRNA splicing endonuclease 15 homolog (S. cerevisiae) ; tRNA splicing endonuclease subunit Sen15; tRNA-intron endonuclease SEN15; tRNA-splicing endonuclease subunit SEN15; Tsen15.

Immunogen: KLH conjugated synthetic peptide derived from human C1orf19/SEN15:51-150/171

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: