C2CD3 Antibody | 8169

C2CD3 Antibody | 8169 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: C2CD3 antibody was raised against an 18 amino acid peptide near the center of human C2CD3.
The immunogen is located within amino acids 1490 - 1540 of C2CD3.

Research Area: Homeostasis, Signal Transduction

Tested Application: E, WB

Application: C2CD3 antibody can be used for detection of C2CD3 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Specificiy: C2CD3 antibody is human, mouse and rat reactive.

Positive Control 1: Cat. No. 1287 - EL4 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 216, 259 kDa
Observed: 255 kDa

Validation: N/A

Isoform: N/A

Purification: C2CD3 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: C2CD3 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: C2CD3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: C2 calcium-dependent domain containing 3, C2 domain-containing protein 3

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: C2CD3, a putative calcium-dependent lipid-binding protein, is an essential regulator of intracellular transduction of the Hedgehog signal (1) . It is localized at the basal body of cilia, mediates calcium-dependent vesicular transport and/or recruitment of proteins and regulates cilium biogenesis by promoting the assembly of centriolar distal appendages critical for docking ciliary vesicles and recruiting other essential ciliogenic proteins (2, 3) . C2CD3 directly promotes centriole elongation and OFD1 acts as a negative regulator of C2CD3 (4, 5) .