C4BPB polyclonal Antibody | BS8157

C4BPB polyclonal Antibody | BS8157 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:2000 IHC/IF: 1:50~1:200

Background: Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through Antibody targeting of foreign antigen. Structurally, C4BP is a disulfide linked, multimeric protein that is composed of seven α chains and one β chain. C4BP functions as a cofactor for C3β inactivator in the cleavage of C3β, and accelerates the decay of C4βC2α (C3 convertase) by acting as a cofactor in the cleavage of C4β by factor I. Streptococcal strains that express Ig-binding cell surface molecules, which are members of the M protein family,can bind to overlapping C4β binding sites in C4BP and therefore, interfere with the classical pathway of complement activation. Bacteria-bound C4BP may be an evolved mechanism that downregulates complement activation in the bacterial host microenvironment, thereby reducing the occurances of bacterial opsonization and phagocytosis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: C4BPB polyclonal Antibody detects endogenous levels of C4BPB protein.

Molecular Weight: ~ 54 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: C4b-binding protein beta chain; C4BPB

Immunogen: Recombinant full length Human C4BPB.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: