C646, p300/CBP Inhibitor | 1948

Cell-permeable. A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor (Ki = 400 nM). Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.

C646, p300/CBP Inhibitor is a reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor (Ki = 400 nM). Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.

1948 | C646, p300/CBP Inhibitor DataSheet

Alternate Name/Synonyms: (E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

Appearance: Red solid

Formulation: N/A

CAS Number: 328968-36-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₁₉N₃O₆

Molecular Weight: 445.42

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: DMSO (25 mM)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor

MDL Number: MFCD01784780

PubChem CID: 1285941

SMILES: CC1=C(C=C(C(=C1)C2=CC=C(O2)C=C3C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C

InChi: InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-

InChi Key: HEKJYZZSCQBJGB-UNOMPAQXSA-N