CA-074 | B2971

CA-074 is an epoxysuccinyl peptide inhibitor of cathepsin B. It selectively inhibits cathepsin B with an IC₅₀ of 2.24 nM over other cysteine proteinases such as cathepsins L and H, and calpains. It inhibits cathepsins H, L and calpain with IC₅₀ values of 172 μM, 420 μM and 200 μM. Intraperitoneal administration (50 mg/kg) of CA-074 reduces metastasis in 4T1.2 mouse xenograft model. It reduces mercury induced expression of inflammatory cytokines in mice.

CA-074 is an epoxysuccinyl peptide inhibitor of cathepsin B. It selectively inhibits cathepsin B with an IC₅₀ of 2.24 nM over other cysteine proteinases such as cathepsins L and H, and calpains. It inhibits cathepsins H, L and calpain with IC₅₀ values of 172 μM, 420 μM and 200 μM. Intraperitoneal administration (50 mg/kg) of CA-074 reduces metastasis in 4T1.2 mouse xenograft model. It reduces mercury induced expression of inflammatory cytokines in mice.

B2971 | CA-074 DataSheet

Alternate Name/Synonyms: (2S)-1-[(2S,3S)-3-methyl-2-[[(2S,3S)-3-(propylcarbamoyl)oxirane-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carboxylic acid; Cathepsin B Inhibitor III; N-{[(2S,3S)-3-(propylcarbamoyl)oxiran-2-yl]carbonyl}-L-isoleucyl-L-proline

Appearance: Solid

Formulation:

CAS Number: 134448-10-5

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₈H₂₉N₃O₆

Molecular Weight: 383.44

Cell-Permeable?: False

Purity: 98%

Solubilities: ~8 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of cathepsin B

MDL Number:

PubChem CID: 9821383

SMILES: CCCNC(=O)C1C(O1)C(=O)NC(C(C)CC)C(=O)N2CCCC2C(=O)O

InChi: InChI=1S/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)/t10-,11-,12-,13-,14-/m0/s1

InChi Key: ZEZGJKSEBRELAS-PEDHHIEDSA-N