CABP1 Antibody (C-term) [AMM05659G]

CABP1 Antibody (C-term) [AMM05659G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This CABP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-343 amino acids from the C-terminal region of human CABP1.

Cellular Localisation: Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus Cell junction, synapse, postsynaptic density. Note=L- CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane [Isoform S-CaBP1]: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor Note=S-CaBP1 is localized at or near the plasma membrane

Molecular Weight: 39838

Clone: Polyclonal

Gene Name: CABP1

Gene ID: 9478

Function: Modulates calcium-dependent activity of inositol 1, 4, 5- triphosphate receptors (ITPRs) (PubMed:14570872) . Inhibits agonist- induced intracellular calcium signaling (PubMed:15980432) . Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310) . Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C- terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941) . Suppresses the calcium-dependent inactivation of CACNA1D (By similarity) . Inhibits TRPC5 channels (PubMed:15895247) . Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity) .

Summary: Tissue Location: Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Calcium-binding protein 1, CaBP1, Calbrain, Caldendrin, CABP1