CaCCinh-A01 | B2014

CaCCinh-A01 is a TMEM16 Blocker. It is a non-selective inhibitor of calcium-activated chloride channels (CaCCs) that blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelium (mean IC₅₀ = 10 µM).

CaCCinh-A01 is a TMEM16 Blocker. It is a non-selective inhibitor of calcium-activated chloride channels (CaCCs) that blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelium (mean IC₅₀ = 10 µM).

B2014 | CaCCinh-A01 DataSheet

Alternate Name/Synonyms: 6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid; TMEM16-Blocker I

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 407587-33-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₁NO₄S

Molecular Weight: 347.43

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A non-selective inhibitor of calcium-activated chloride channels (CaCCs)

MDL Number: N/A

PubChem CID: 2898877

SMILES: CC(C)(C)C1CCC2=C(C1)SC(=C2C(=O)O)NC(=O)C3=CC=CO3

InChi: InChI=1S/C18H21NO4S/c1-18(2,3)10-6-7-11-13(9-10)24-16(14(11)17(21)22)19-15(20)12-5-4-8-23-12/h4-5,8,10H,6-7,9H2,1-3H3,(H,19,20)(H,21,22)

InChi Key: ACLUEOBQFRYTQS-UHFFFAOYSA-N