CACNB1 Antibody (C-term) [APR04073G]

CACNB1 Antibody (C-term) [APR04073G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CACNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 543-572 amino acids from the C-terminal region of human CACNB1.

Cellular Localisation: Cell membrane, sarcolemma; Peripheral membrane protein {ECO:0000250|UniProtKB:P19517}; Cytoplasmic side {ECO:0000250|UniProtKB:P19517}. Cell membrane; Peripheral membrane protein

Molecular Weight: 65714

Clone: Polyclonal

Gene Name: CACNB1

Gene ID: 782

Function: Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847) . Regulates the activity of L-type calcium channels that contain CACNA1A as pore- forming subunit (By similarity) . Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847) . Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651) . Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964) .

Summary: Tissue Location: Detected in heart ventricle (at protein level) (PubMed:15615847) . Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Voltage-dependent L-type calcium channel subunit beta-1, CAB1, Calcium channel voltage-dependent subunit beta 1, CACNB1, CACNLB1