CAD Polyclonal Antibody | E-AB-17759

CAD Polyclonal Antibody | E-AB-17759 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Aspartate carbamoyltransferase, Aspartate transcarbamylase, CAD protein, CAD trifunctional protein, Carbamoyl phosphate synthetase 2, Carbamoyl-phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase, CPSase ATCase DHOase, Dihydroorotase, Glutamine dependent carbamoyl phosphate synthase, Multifunctional protein CAD

Application: IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism

Background: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.

Concentration: 0.7 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human CAD

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A