CAL-101 (GS-1101) | 2613

CAL-101 is a cell-permeable inhibitor of the PI3K catalytic subunit p110δ (IC₅₀ = 2.5 nM) that displays 40- to 300-fold selectivity against other PI3K class I enzymes (IC₅₀s = 820, 565, and 89 nM for p110α, β, and γ, respectively). It has also been shown to inhibit the chemotaxis of chronic lymphocytic leukemia cells and to downregulate the secretion of chemokines triggered by B-cell receptor signaling.

CAL-101 is a cell-permeable inhibitor of the PI3K catalytic subunit p110δ (IC₅₀ = 2.5 nM) that displays 40- to 300-fold selectivity against other PI3K class I enzymes (IC₅₀s = 820, 565, and 89 nM for p110α, β, and γ, respectively). It has also been shown to inhibit the chemotaxis of chronic lymphocytic leukemia cells and to downregulate the secretion of chemokines triggered by B-cell receptor signaling.

2613 | CAL-101 (GS-1101) DataSheet

Alternate Name/Synonyms: 5-​fluoro-​3-​phenyl-​2-​[(1S)-​1-​(9H-​purin-​6-​ylamino)propyl]-​4(3H)-​quinazolinone; Idealisib

Appearance: White solid

Formulation: N/A

CAS Number: 870281-82-6

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₁₈FN₇O

Molecular Weight: 415.42

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO(~ 25 mg/ml) or EtOH (~ 15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent PI3K p110δ inhibitor

MDL Number: N/A

PubChem CID: 11625818

SMILES: CCC(C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

InChi: InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1

InChi Key: IFSDAJWBUCMOAH-HNNXBMFYSA-N