Caldesmon Rabbit monoclonal Antibody | BS9915M

Caldesmon Rabbit monoclonal Antibody | BS9915M | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB ICC/IF IHC FC

Application Range: WB: 1:1000-1:2000 IHC/ICC/IF: 1:50-1:200 FC: 1:50-1:100

Background: Caldesmon, Filamin 1, Nebulin and Villin are differentially expressed and regulated Actin binding proteins. Both muscular and non-muscular forms of Caldesmon have been identified and each has been shown to bind to Actin as well as to calmodulin and Myosin. Alternative splicing of the gene encoding Caldesmon results in five isoforms. Muscular Caldesmon (isoform 1), also designated high molecular weight Caldesmon or H-Caldesmon (H-CAD), is expressed predominantly on thin filaments in smooth muscle. Non-muscular Caldesmon (isoforms 2-5), also designated low molecular weight Caldesmon or L-Caldesmon (L-CAD), is widely expressed in non-muscle tissues and cells.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of Caldesmon and does not cross-react with related proteins.

Molecular Weight: 70-80 kDa non-muscle 120-150 kDa smooth muscle

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Caldesmon; CDM; CALD1; CAD; CDM

Immunogen: Recombinant Antibody.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein A affinity purified

Pathway: