Calpain Inhibitor I, ALLN | 1834

A cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.

Calpain Inhibitor I, ALLN is a ell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM).

1834 | Calpain Inhibitor I, ALLN DataSheet

Alternate Name/Synonyms: Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Nle-al

Appearance: White powder

Formulation: N/A

CAS Number: 110044-82-1

Structure Available?: Yes

Peptide sequence: Ac-Leu-Leu-Nile-CHO

Salt Form: No

Molecular Formula: C₂₀H₃₇N₃O₄

Molecular Weight: 383.54

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (25 mg/ml) or EtOH

Handling: Protect from moisture and air

Country of Origin: USA

Tag Line: A Calpain inhibitor

MDL Number: MFCD00065505

PubChem CID: 443118

SMILES: CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C

InChi: InChI=1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17 (10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H, 23,27)/t16-,17-,18-/m0/s1

InChi Key: FMYKJLXRRQTBOR-BZSNNMDCSA-N