Calpain Inhibitor II, ALLM | 1835

A cell-permeable inhibitor of calpain 1 (Ki = 120 nM) and calpain 2 (Ki = 230 nM). Also potently inhibits cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin’s Lymphoma cells.

Calpain Inhibitor II, ALLM is a cell-permeable inhibitor of calpain 1 (Ki = 120 nM) and calpain 2 (Ki = 230 nM). Also potently inhibits cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin’s Lymphoma cells.

1835 | Calpain Inhibitor II, ALLM DataSheet

Alternate Name/Synonyms: Ac-LLM-CHO, N-Acetyl-Leu-Leu-Methional

Appearance: White powder

Formulation: N/A

CAS Number: 136632-32-1

Structure Available?: Yes

Peptide sequence: N-Acetyl-Leu-Leu-Methional

Salt Form: No

Molecular Formula: C₁₉H₃₅N₃O₄S

Molecular Weight: 401.57

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (25 mg/ml) or EtOH (25 mg/ml)

Handling: Protect from moisture and air

Country of Origin: USA

Tag Line: A Calpain inhibitor

MDL Number: MFCD00065506

PubChem CID: 4331

SMILES: CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCSC)C=O)NC(=O)C

InChi: InChI=1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18 (25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21, 25)(H,22,26)

InChi Key: RJWLAIMXRBDUMH-UHFFFAOYSA-N