Calreticulin, human recombinant | 7570

Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the ‘calreticulin/calnexin cycle’ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.

7570 | Calreticulin human recombinant DataSheet

Biomolecule/Target: Calreticulin

Synonyms: CRP55; Calregulin; Endoplasmic Reticulum Resident Protein 60; ERp60; grp60

Alternates names: Fibroblast growth factor 19

Taglines: Involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity

NCBI Gene ID #: 9965

NCBI Gene Symbol: FGF19

Gene Source: Human

Accession #: NM_005117

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <0.1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: Determined by a cell proliferation assay using balb/c 3T3 cells. The expected ED for this effect is 50-200 ng/ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 21.8 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: 0.2 m-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1 to 1.0 µg/µl. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A