Cambinol | 1653

An inhibitor of NAD-dependent deacetylase activity of human SIRT1 (IC₅₀ = 56 µM) and SIRT2(IC₅₀ = 59 µM). Acts as an antitumor agent. Treatment of BCL6-expressing Burkitt lymphoma cells with Cambinol induces apoptosis accompanied by hyperacetylation of BCL6 and p53.

Cambinol is an inhibitor of NAD-dependent deacetylase activity of human SIRT1 (IC₅₀ = 56 µM) and SIRT2(IC₅₀ = 59 µM). Acts as an antitumor agent.

1653 | Cambinol DataSheet

Alternate Name/Synonyms: 5-[(2-hydroxy-5,8-dihydronaphthalen-1-yl)methyl]-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; NSC-112546

Appearance: White solid

Formulation: N/A

CAS Number: 14513-15-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₆N₂O₂S

Molecular Weight: 360.43

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A SIRT1 inhibitor

MDL Number: MFCD09057543

PubChem CID: 3246390

SMILES: C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O

InChi: InChI=1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7- 2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26)

InChi Key: RVNSQVIUFZVNAU-UHFFFAOYSA-N