CAMK2A (CAMK2 alpha) Antibody (C-term) [APG02351G]

CAMK2A (CAMK2 alpha) Antibody (C-term) [APG02351G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CAMK2A (CAMK2 alpha) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 446-478 amino acids from the C-terminal region of human CAMK2A (CAMK2 alpha) .

Cellular Localisation: Cell junction, synapse {ECO:0000250|UniProtKB:P11275}. Cell junction, synapse, postsynaptic density {ECO:0000250|UniProtKB:P11275}. Cell projection, dendritic spine. Cell projection, dendrite. Note=Postsynaptic lipid rafts {ECO:0000250|UniProtKB:P11275}

Molecular Weight: 54088

Clone: Polyclonal

Gene Name: CAMK2A

Gene ID: 815

Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca (2+) /calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity) . Regulates dendritic spine development (PubMed:28130356) . Also regulates the migration of developing neurons (PubMed:29100089) . Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378) . Acts as a negative regulator of 2- arachidonoylglycerol (2-AG) -mediated synaptic signaling via modulation of DAGLA activity (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000

Synonyms: Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, CAMK2A, CAMKA, KIAA0968