Camptothecin (2 mg/ml) | 1039

Reversibly inhibits nuclear topoisomerase I by binding to and stabilizing the topoisomerase-DNA covalent complex. Inhibits Tat-mediated transcription of HIV-1. Induces apoptosis in Jurkat, osteosarcoma and hepatoma cells.

Camptothecin is a reversible inhibitor of nuclear Topoisomerase I

1039 | Camptothecin (2 mg/ml) DataSheet

Alternate Name/Synonyms: (S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione

Appearance: Liquid

Formulation: DMSO ( 2 mg/ml)

CAS Number: 7689-03-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₆N₂O₄

Molecular Weight: 348.4

Cell-Permeable?: Yes

Purity: >98% by TLC

Solubilities: N/A

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A topoisomerase I inhibitor

MDL Number: MFCD00081076

PubChem CID: 24360

SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

InChi: InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1

InChi Key: VSJKWCGYPAHWDS-FQEVSTJZSA-N