CAPN3 polyclonal Antibody | BS7696

CAPN3 polyclonal Antibody | BS7696 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Calpain, an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, plays a role in cytoskeletal reorganization and muscle protein degradation. Calpain is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits, designated calpain 1, calpain 2 and calpain 3. Calpain 3 (calpain p94) is a muscle-preferred calcium activated neutral protease that localizes to the nucleus. Mutations involving the calpain 3 gene are associated with limb-girdle muscle dystrophy type 2A, a form of autosomal recessive and progressive neuromuscular diso4. Calpastatin regulates calpain by inhibiting both the proteolytic activity of calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CAPN3 polyclonal Antibody detects endogenous levels of CAPN3 protein.

Molecular Weight: ~ 114 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Calcium activated neutral proteinase 3; Calcium activated neutral proteinase 3; Calcium-activated neutral proteinase 3; calpain 3, (p94) ; Calpain L3; Calpain large polypeptide L3; Calpain large polypeptide L3; Calpain p94; calpain p94, large [catalytic] subunit; calpain, large polypeptide L3; Calpain-3; CAN3_HUMAN; CANP 3; CANP3; CANPL3; CAPN 3; CAPN3; LGMD 2A; LGMD2; LGMD2A; Limb girdle muscular dystrophy 2A; Limb girdle muscular dystrophy 2A; Lp82; LP85; MGC10767; MGC11121; MGC14344; MGC4403; Muscle specific calcium activated neutral protease 3; Muscle-specific calcium-activated neutral protease 3; muscle-specific calcium-activated neutral protease 3 large subunit; nCL-1; nCL1; New calpain 1; p94;

Immunogen: Recombinant full length Human CAPN3.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: