Capsaicin | 2521

Capsaicin is the ingredient found in different types of hot peppers, such as cayenne peppers, that makes the peppers spicy hot. Prototype vanilloid receptor agonist (pEC₅₀ values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Activates sensory neurons that give rise to unmyelinated C-fibers, many of which contain substance P. Topical application desensitizes the sensory nerve endings giving a paradoxical antinociceptive effect.

Capsaicin is the ingredient found in different types of hot peppers, such as cayenne peppers, that makes the peppers spicy hot. Prototype vanilloid receptor agonist (pEC₅₀ values are 7.97 and 7.10 at rat and human VR1 receptors respectively).

2521 | Capsaicin DataSheet

Alternate Name/Synonyms: E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

Appearance: White solid

Formulation: N/A

CAS Number: 404-86-4

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₇NO3

Molecular Weight: 305.42

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~15 mg/ml) or EtOH (~15 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An antinociceptive agent

MDL Number: MFCD00017259

PubChem CID: 1548943

SMILES: CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC

InChi: InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+

InChi Key: YKPUWZUDDOIDPM-SOFGYWHQSA-N