Captopril | B1187

Captopril is an angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ = 0.022 μM). Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and competitively (Ki = 6.0 μM for leukotriene B4> formation and Ki = 60 nM for L-lysine-p-nitroanilide). Displays vasodilatory and antihypertensive effects in vivo. Clinically useful antihypertensive agent.

Captopril is an angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ = 0.022 μM). Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and competitively (Ki = 6.0 μM for leukotriene B4> formation and Ki = 60 nM for L-lysine-p-nitroanilide). Displays vasodilatory and antihypertensive effects in vivo. Clinically useful antihypertensive agent.

B1187 | Captopril DataSheet

Alternate Name/Synonyms: (2S)-1-(3-Mercapto-2-methyl-propionyl)-L-proline

Appearance: White solid

Formulation: N/A

CAS Number: 62571-86-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₉H₁₅NO₃S

Molecular Weight: 217.28

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An angiotensin-converting enzyme (ACE) inhibitor

MDL Number: MFCD00168073

PubChem CID: 44093

SMILES: CC(CS)C(=O)N1CCCC1C(=O)O

InChi: InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChi Key: FAKRSMQSSFJEIM-RQJHMYQMSA-N