CARD6 (A2) polyclonal Antibody | BS1038

CARD6 (A2) polyclonal Antibody | BS1038 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: IHC IF

Application Range: IHC: 1:50~1:200 IF: 1:50~1:200

Background: Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1–3) and the caspase-associated recruitment domain (CARD) proteins, CARD 6, CARD 8-12 and CARD 14. CARD 6 is a 311 amino acid protein that associates with microtubules and acts as a selective mediator of NFκB activation. CARD 6 is structurally and functionally related to the superfamily of interferon (IFN) -inducible GTPases, a group that comprises host defense proteins which mediate cell-autonomous immunity. RICK, the receptorinteracting protein (RIP) -like interacting caspase-like apoptosis regulatory protein kinase, interacts with CARD 6 and targets it to aggresomes, regions of the cell where protein aggregates collect.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CARD6/CINCIN1 (A2) polyclonal Antibody detects endogenous levels of CARD6/CIN protein.

Molecular Weight: ~ 116 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Caspase recruitment domain-containing protein 6; CARD-6

Immunogen: Synthetic peptide, corresponding to the N-terminual of Human CARD6.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: