Carmustine | B2658

Carmustine is a nitrogen mustard and a cell-cycle phase nonspecific alkylating antineoplastic agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. It is used in the treatment of brain tumors and various other malignant neoplasms.

Carmustine is a nitrogen mustard and a cell-cycle phase nonspecific alkylating antineoplastic agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. It is used in the treatment of brain tumors and various other malignant neoplasms.

B2658 | Carmustine DataSheet

Alternate Name/Synonyms: bis-Chloroethylnitrosourea; N,N'-Bis(2-chloroethyl)-N-nitrosourea; BCNU; Gliadel; NSC 409962

Appearance: Amorphous solid

Formulation:

CAS Number: 154-93-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₅H₉Cl₂N₃O₂

Molecular Weight: 214.05

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~20 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A nitrogen mustard and a DNA alkylating agent

MDL Number: MFCD00057706

PubChem CID: 2578

SMILES: ClCCNC(N(N=O)CCCl)=O

InChi: InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)

InChi Key: DLGOEMSEDOSKAD-UHFFFAOYSA-N