Casein Kinase Iα (phospho-Y321) polyclonal Antibody | BS4602

Casein Kinase Iα (phospho-Y321) polyclonal Antibody | BS4602 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Casein kinase I (also designated CKI) and casein kinase II (also designated CKII) compose a family of serine/threonine protein kinases which are present in all eukaryotes examined to date. CKI family members, which include CKIα, β, γ, e and δ, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an α2β2 or an αα'β2 structure. The a catalytic subunit is stimulated by the β regulatory subunit, which undergoes autophosphorylation. CKII activity is high in the cytosol and nucleus of proliferating and differentiating cells. CKII is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-Casein Kinase Iα (Y321) pAb detects endogenous levels of Casein Kinase Iα protein only when phosphorylated at Tyr321.

Molecular Weight: ~ 34 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1; CKIα; CK-Iα; CKI-α; CK Iα

Immunogen: Synthetic phosphopeptide derived from human Casein Kinase Iα around the phosphorylation site of Tyrosine 321

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Phosphoinosotode Signaling,Protein Kinase C Signaling,Regulation of Actin Dynamics,Warburg Effect,Regulation of Microtubule Dynamics,SAPK JNK Signaling Cascades,Inhibition of Apoptosis,G Protein-coupled Receptors Signaling to MAPK Erk,Mitochondrial Control of Apoptosis,